The trip's actually nowhere near as difficult as you might think. There are some warnings, some things that you need to be careful of ... I'll try to outline them without offending anybody.
Woomera - about as exciting as watching acrylic paint drying (which is nowhere near as much fun as enamel). Even if you like missiles and warplanes, you still need a blue pill in that town to get excited.
Glendambo - good fuel.
Coober Pedy - it's a dust bowl. Can be spotted from 30km on either side of town by the mounds of dirt that they've dug up. The town deserves some exploration, we didn't give it the chance. The Caltex sells good fuel but don't go there in the afternoon, the local tribe wanders straight through looking for their daily ration of beer.
Marla - do NOT stop to help anybody on the highway within 30 mins travel on either side. Ask at the Shell servo for a recovery crew to go out and help the "stranded" people, but by the time you've refuelled there and paid for it, the "stranded" cars will show up and everyone will pour out of the vehicle screaming and yelling and generally looking like something to stay well clear of.
Laseter Highway - do NOT buy fuel on this road. Get it at the Shell at Erldunda, or get it at Yulara resort. You'll save yourself about 50 cents per litre.
If you're doing the tourist thing: visit Kings Canyon FIRST. Walk the canyon first thing in the morning, then visit Kathleen Springs, Kings Creek Station (Kings Creek Station fuel is GOOD and cheaper than Kings Canyon Resort). On your way back towards Yulara/Uluru, turn onto the Ernest Giles Road ONLY for the photo op. Put the vehicle in 4WD mode immediately and keep some speed up, there is some really, really soft sand near some trees not far from the sealed road. Then move to Yulara and enjoy.
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